Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- NF-kappa-B/Dorsal
- Interferon regulatory factor, DNA-binding domain
- Rel homology domain, DNA-binding domain
- Interferon regulatory factor, conserved site
- Winged helix DNA-binding domain superfamily
- Winged helix-like DNA-binding domain superfamily
- Rel homology dimerisation domain
- NFkappaB IPT domain
8 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115708 (preferred)
Entry contents:
2 distinct polypeptide molecules
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (4 distinct):
Interferon regulatory factor 3; Interferon regulatory factor 7; Transcription factor p65
Molecule details ›
Chain: A
Length: 540 amino acids
Theoretical weight: 61.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 540 amino acids
Theoretical weight: 61.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q04206 (Residues: 20-291; Coverage: 49%) - Canonical: Q92985 (Residues: 8-125; Coverage: 24%)
- Canonical: Q14653 (Residues: 9-111; Coverage: 24%)
Sequence domains:
- Rel homology DNA-binding domain
- Rel homology dimerisation domain
- Interferon regulatory factor transcription factor
Nuclear factor NF-kappa-B p50 subunit
Molecule details ›
Chain: B
Length: 314 amino acids
Theoretical weight: 35.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 314 amino acids
Theoretical weight: 35.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P19838 (Residues: 40-352; Coverage: 32%)
Sequence domains:
Structure domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ALS BEAMLINE 8.2.1
Spacegroup:
P212121
Expression system: Escherichia coli
