2o6g

X-ray diffraction
3.1Å resolution

Crystal structure of IRF-3 bound to the interferon-b enhancer

Released:
Source organism: Homo sapiens
Primary publication:
An atomic model of the interferon-beta enhanceosome.
Cell 129 1111-23 (2007)
PMID: 17574024

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-115709 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Interferon regulatory factor 3 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 123 amino acids
Theoretical weight: 14.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14653 (Residues: 1-123; Coverage: 29%)
Gene name: IRF3
Sequence domains: Interferon regulatory factor transcription factor
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
interferon-b enhancer Chain: D
Molecule details ›
Chain: D
Length: 57 nucleotides
Theoretical weight: 17.84 KDa
Source organism: Homo sapiens
Expression system: Not provided
interferon-b enhancer Chain: C
Molecule details ›
Chain: C
Length: 57 nucleotides
Theoretical weight: 17.28 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: I222
Unit cell:
a: 91.02Å b: 105.32Å c: 353.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.251 0.265
Expression systems:
  • Escherichia coli
  • Not provided