› 2o71

X-ray diffraction
2Å resolution

Crystal structure of RAIDD DD

Released:
DOI: 10.2210/pdb2o71/pdb
PDB entry 2o71 coloured by chain, front view.
PDB entry 2o71 coloured by chain, side view.
PDB entry 2o71 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly.
Park HH, Wu H
J Mol Biol 357 358-64 (2006)
PMID: 16434054

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160287 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Death domain-containing protein CRADD Chain: A
Molecule details ›
Chain: A
Length: 115 amino acids
Theoretical weight: 13.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P78560 (Residues: 94-199; Coverage: 53%)
Gene names: CRADD, RAIDD
Sequence domains: Death domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P3121
Unit cell:
a: 56.058Å b: 56.058Å c: 64.915Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.231 0.231 0.241
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Caspase functions in cell death and disease.
McIlwain et al. (2013)
7 more

7 mentions without citation

Activation and assembly of the inflammasomes through conserved protein domain families.
Jin et al. (2015)
6 more