› 2o95

X-ray diffraction
1.95Å resolution

Crystal Structure of the Metal-Free Dimeric Human Mov34 MPN domain (residues 1-186)

Released:
DOI: 10.2210/pdb2o95/pdb
PDB entry 2o95 coloured by chain, front view.
PDB entry 2o95 coloured by chain, side view.
PDB entry 2o95 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of the human Mov34 MPN domain reveals a metal-free dimer.
Sanches M, Alves BS, Zanchin NI, Guimarães BG
J Mol Biol 370 846-55 (2007)
PMID: 17559875

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-156388 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
26S proteasome non-ATPase regulatory subunit 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 187 amino acids
Theoretical weight: 21.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51665 (Residues: 1-186; Coverage: 57%)
Gene names: MOV34L, PSMD7
Sequence domains: JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Structure domains: Cytidine Deaminase, domain 2

Ligands and Environments

5 bound ligands:
Ligand SO4 3 x SO4
Ligand 12P 1 x 12P
Ligand PG4 1 x PG4
Ligand PGE 4 x PGE
Ligand ETE 1 x ETE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: C2
Unit cell:
a: 114.103Å b: 95.289Å c: 58.988Å
α: 90° β: 121.13° γ: 90°
R-values:
R R work R free
0.203 0.201 0.24
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Structural biology of the proteasome.
Kish-Trier et al. (2013)
10 more

7 mentions without citation

Molecular architecture and assembly of the eukaryotic proteasome.
Tomko et al. (2013)
6 more