› 2oay

X-ray diffraction
2.35Å resolution

Crystal structure of latent human C1-inhibitor

Released:
DOI: 10.2210/pdb2oay/pdb
PDB entry 2oay coloured by chain, front view.
PDB entry 2oay coloured by chain, side view.
PDB entry 2oay coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease.
Beinrohr L, Harmat V, Dobó J, Lörincz Z, Gál P, Závodszky P
J Biol Chem 282 21100-9 (2007)
PMID: 17488724

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138561 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasma protease C1 inhibitor Chain: A
Molecule details ›
Chain: A
Length: 390 amino acids
Theoretical weight: 43.9 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P05155 (Residues: 119-500; Coverage: 80%)
Gene names: C1IN, C1NH, SERPING1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 1 x NAG
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P65
Unit cell:
a: 98.903Å b: 98.903Å c: 94.684Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.176 0.174 0.218
Expression system: Komagataella pastoris

Quick links

Citations

14 review citations

Biological activities of C1 inhibitor.
Davis et al. (2008)
13 more

5 mentions without citation

Presence of C1-inhibitor polymers in a subset of patients suffering from hereditary angioedema.
Madsen et al. (2014)
4 more