› 2oby

X-ray diffraction
3Å resolution

Crystal structure of Human P53 inducible oxidoreductase (TP53I3,PIG3)

Released:
DOI: 10.2210/pdb2oby/pdb
PDB entry 2oby coloured by chain, front view.
PDB entry 2oby coloured by chain, side view.
PDB entry 2oby coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Porte S, Valencia E, Farres J, Fita I, Pike ACW, Shafqat N, Debreczeni J, Johansson C, Haroniti A, Gileadi O, Arrowsmith CH, Edwards A, Weigelt J, Sundstrom M, von Delft F, Oppermann U, Pares X

Function and Biology Details

Reaction catalysed: 
NADPH + 2 quinone = NADP(+) + 2 semiquinone
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176093 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Quinone oxidoreductase PIG3 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 338 amino acids
Theoretical weight: 36.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q53FA7 (Residues: 1-332; Coverage: 100%)
Gene names: PIG3, TP53I3
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAP 5 x NAP
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2221
Unit cell:
a: 68.354Å b: 184.359Å c: 318.047Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.22 0.26
Expression system: Escherichia coli BL21

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