› 2odb

X-ray diffraction
2.4Å resolution

The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)

Released:
DOI: 10.2210/pdb2odb/pdb
PDB entry 2odb coloured by chain, front view.
PDB entry 2odb coloured by chain, side view.
PDB entry 2odb coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Yang X, Elkins J, Soundararajan M, Pike ACW, Eswaran J, Burgess N, Debreczeni JE, Sundstrom M, Arrowsmith C, Weigelt J, Edwards A, Gileadi O, von Delft F, Knapp S, Doyle D, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
GTP + H(2)O = GDP + phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-158145 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cell division control protein 42 homolog Chain: A
Molecule details ›
Chain: A
Length: 192 amino acids
Theoretical weight: 21.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P60953 (Residues: 1-191; Coverage: 100%)
Gene name: CDC42
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Serine/threonine-protein kinase PAK 6 Chain: B
Molecule details ›
Chain: B
Length: 35 amino acids
Theoretical weight: 4.07 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9NQU5 (Residues: 11-45; Coverage: 5%)
Gene names: PAK5, PAK6
Sequence domains: P21-Rho-binding domain

Ligands and Environments

4 bound ligands:
Ligand CL 1 x CL
Ligand MG 1 x MG
Ligand SO4 3 x SO4
Ligand GCP 1 x GCP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P6522
Unit cell:
a: 162.366Å b: 162.366Å c: 45.968Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.203 0.232
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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