Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|- bond in complement component C5 alpha-chain to form C5a and C5b.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Serine proteases, trypsin domain
- Peptidase S1A, chymotrypsin family
- von Willebrand factor, type A
- Peptidase S1, PA clan, chymotrypsin-like fold
- von Willebrand factor A-like domain superfamily
- Serine proteases, trypsin family, serine active site
- Serine proteases, trypsin family, histidine active site
- Peptidase S1, PA clan
1 more domain
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Complement C2 (preferred)
PDBe Complex ID:
PDB-CPX-177326 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Complement C2
Molecule details ›
Chain: A
Length: 509 amino acids
Theoretical weight: 57.46 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Structure domains:
Length: 509 amino acids
Theoretical weight: 57.46 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q5JP69 (Residues: 244-752; Coverage: 70%)
Sequence domains:
Structure domains:
