› 2odt

X-ray diffraction
2.01Å resolution

Structure of human Inositol 1,3,4-trisphosphate 5/6-kinase

Released:
DOI: 10.2210/pdb2odt/pdb
PDB entry 2odt coloured by chain, front view.
PDB entry 2odt coloured by chain, side view.
PDB entry 2odt coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Busam RD, Arrowsmith C, Berglund H, Collins R, Edwards A, Ericsson UB, Flodin S, Flores A, Hammarstrom M, Holmberg SL, Johansson I, Karlberg T, Kotenyova T, Moche M, Nilsson ME, Nordlund P, Nyman T, Ogg D, Sagemark J, Sundstrom M, Uppenberg J, Van Den Berg S, Weigelt J, Persson C, Thorsell AG, Hallberg BM, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171765 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol-tetrakisphosphate 1-kinase Chain: X
Molecule details ›
Chain: X
Length: 328 amino acids
Theoretical weight: 37.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13572 (Residues: 1-327; Coverage: 79%)
Gene name: ITPK1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 7 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 61.33Å b: 39.55Å c: 67.39Å
α: 90° β: 98.4° γ: 90°
R-values:
R R work R free
0.181 0.177 0.257
Expression system: Escherichia coli

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