› 2odv

X-ray diffraction
2.05Å resolution

Crystal structure of a fragment of the plakin domain of plectin, Cys to Ala mutant.

Released:
DOI: 10.2210/pdb2odv/pdb
PDB entry 2odv coloured by chain, front view.
PDB entry 2odv coloured by chain, side view.
PDB entry 2odv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of a tandem pair of spectrin repeats of plectin reveals a modular organization of the plakin domain.
Sonnenberg A, Rojas AM, de Pereda JM
J Mol Biol 368 1379-91 (2007)
PMID: 17397861

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172226 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plectin Chain: A
Molecule details ›
Chain: A
Length: 235 amino acids
Theoretical weight: 27.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15149 (Residues: 410-640; Coverage: 5%)
Gene names: PLEC, PLEC1
Sequence domains: Spectrin-like repeat
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1

Ligands and Environments

1 bound ligand:
Ligand PGO 1 x PGO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21212
Unit cell:
a: 154.62Å b: 26.51Å c: 58.09Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.256
Expression system: Escherichia coli BL21(DE3)

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Citations

17 review citations

Introducing intermediate filaments: from discovery to disease.
Eriksson et al. (2009)
16 more

3 mentions without citation

In vivo epidermal migration requires focal adhesion targeting of ACF7.
Yue et al. (2016)
2 more