› 2ofs

X-ray diffraction
2.12Å resolution

Crystal structure of human CD59

Released:
DOI: 10.2210/pdb2ofs/pdb
PDB entry 2ofs coloured by chain, front view.
PDB entry 2ofs coloured by chain, side view.
PDB entry 2ofs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack complex.
Huang Y, Fedarovich A, Tomlinson S, Davies C
Acta Crystallogr D Biol Crystallogr 63 714-21 (2007)
PMID: 17505110

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146830 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD59 glycoprotein Chain: A
Molecule details ›
Chain: A
Length: 75 amino acids
Theoretical weight: 8.77 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P13987 (Residues: 26-99; Coverage: 72%)
Gene names: CD59, MIC11, MIN1, MIN2, MIN3, MSK21
Sequence domains: u-PAR/Ly-6 domain
Structure domains: CD59

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P63
Unit cell:
a: 56.4Å b: 56.4Å c: 39.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.177 0.254
Expression system: Komagataella pastoris

Quick links

Citations

8 review citations

Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.
Loughner et al. (2016)
7 more

3 mentions without citation

Evolution and Medical Significance of LU Domain-Containing Proteins.
Leth et al. (2019)
2 more