› 2ofv

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138958 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Lck Chains: A, B
Molecule details ›
Chains: A, B
Length: 277 amino acids
Theoretical weight: 32.06 KDa
Source organism: Homo sapiens
Expression system: Insect Cell
UniProt:
  • Canonical: P06239 (Residues: 232-498; Coverage: 53%)
Gene name: LCK
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 242 2 x 242
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 142.66Å b: 66.89Å c: 78.51Å
α: 90° β: 112° γ: 90°
R-values:
R R work R free
0.274 0.274 0.301
Expression system: Insect Cell

Quick links

Citations

3 review citations

Update on lymphocyte specific kinase inhibitors: a patent survey.
Martin et al. (2010)
2 more

6 mentions without citation

Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores.
Gógl et al. (2019)
5 more