› 2ol2

X-ray diffraction
2Å resolution

High Resolution Structure of Native PCI in Space Group P21

Released:
DOI: 10.2210/pdb2ol2/pdb
PDB entry 2ol2 coloured by chain, front view.
PDB entry 2ol2 coloured by chain, side view.
PDB entry 2ol2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of native protein C inhibitor provides insight into its multiple functions.
Li W, Adams TE, Kjellberg M, Stenflo J, Huntington JA
J Biol Chem 282 13759-68 (2007)
PMID: 17337440

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138558 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasma serine protease inhibitor Chains: A, B
Molecule details ›
Chains: A, B
Length: 395 amino acids
Theoretical weight: 44.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05154 (Residues: 36-406; Coverage: 96%)
Gene names: PCI, PLANH3, PROCI, SERPINA5
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P21
Unit cell:
a: 56.017Å b: 60.074Å c: 133.171Å
α: 90° β: 93.28° γ: 90°
R-values:
R R work R free
0.225 0.225 0.271
Expression system: Escherichia coli

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Citations

5 review citations

Thrombin inhibition by the serpins.
Huntington JA. (2013)
4 more

8 mentions without citation

Serpins in thrombosis, hemostasis and fibrinolysis.
Rau et al. (2007)
7 more