› 2ol9

X-ray diffraction
0.85Å resolution

Peptide corresponding to residues 170-175 of human prion

Released:
DOI: 10.2210/pdb2ol9/pdb
PDB entry 2ol9 coloured by chain, front view.
PDB entry 2ol9 coloured by chain, side view.
PDB entry 2ol9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic structures of amyloid cross-beta spines reveal varied steric zippers.
Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AØ, Riekel C, Eisenberg D
Nature 447 453-7 (2007)
PMID: 17468747

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
peptide from human prion Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 723 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P1
Unit cell:
a: 14.002Å b: 4.879Å c: 15.1Å
α: 75.23° β: 75.88° γ: 78.89°
R-values:
R R work R free
0.073 0.073 0.078
Expression system: Not provided

Quick links

Citations

270 review citations

The amyloid state and its association with protein misfolding diseases.
Knowles et al. (2014)
269 more

19 mentions without citation

A structural overview of the vertebrate prion proteins.
Pastore et al. (2007)
18 more