› 2om9

X-ray diffraction
2.8Å resolution

Ajulemic acid, a synthetic cannabinoid bound to PPAR gamma

Released:
DOI: 10.2210/pdb2om9/pdb
PDB entry 2om9 coloured by chain, front view.
PDB entry 2om9 coloured by chain, side view.
PDB entry 2om9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ajulemic acid, a synthetic nonpsychoactive cannabinoid acid, bound to the ligand binding domain of the human peroxisome proliferator-activated receptor gamma.
Ambrosio ALB, Dias SMG, Polikarpov I, Zurier RB, Burstein SH, Garratt RC
J Biol Chem 282 18625-18633 (2007)
PMID: 17462987

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 278 amino acids
Theoretical weight: 31.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 232-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand AJA 8 x AJA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P1
Unit cell:
a: 62.344Å b: 78.139Å c: 104.231Å
α: 100.1° β: 106.41° γ: 90.01°
R-values:
R R work R free
0.219 0.217 0.267
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors.
O'Sullivan SE. (2007)
13 more

5 mentions without citation

Molecular Targets of the Phytocannabinoids: A Complex Picture.
Morales et al. (2017)
4 more