› 2ome

X-ray diffraction
2.8Å resolution

Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)

Released:
DOI: 10.2210/pdb2ome/pdb
PDB entry 2ome coloured by chain, front view.
PDB entry 2ome coloured by chain, side view.
PDB entry 2ome coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pilka ES, Guo K, Rojkova A, Debreczeni JE, Kavanagh KL, von Delft F, Arrowsmith CH, Weigelt J, Edwards A, Sundstrom M, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157491 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-terminal-binding protein 2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 336 amino acids
Theoretical weight: 37.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P56545 (Residues: 31-364; Coverage: 75%)
Gene name: CTBP2
Sequence domains:
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

1 bound ligand:
Ligand NAD 8 x NAD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 87.754Å b: 141.574Å c: 138.215Å
α: 90° β: 98.93° γ: 90°
R-values:
R R work R free
0.21 0.207 0.257
Expression system: Escherichia coli BL21(DE3)

Quick links