› 2os6

Solution NMR

Solution structure of LARG PDZ domain in complex with C-terminal octa-peptide of Plexin B1

Released:
DOI: 10.2210/pdb2os6/pdb
PDB entry 2os6 coloured by chain, ensemble of 20 models, front view.
PDB entry 2os6 coloured by chain, ensemble of 20 models, side view.
PDB entry 2os6 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Liu J, Huang H, Yang Y

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128848 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Rho guanine nucleotide exchange factor 12 Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 9.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NZN5 (Residues: 67-151; Coverage: 6%)
Gene names: ARHGEF12, KIAA0382, LARG
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Plexin-B1 Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 918 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O43157 (Residues: 2128-2135; Coverage: 0%)
Gene names: KIAA0407, PLXN5, PLXNB1, SEP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Distance geometry, simulated annealing, molecular dynamics, torsion angle dynamics
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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