› 2ou2

X-ray diffraction
2.3Å resolution

Acetyltransferase domain of Human HIV-1 Tat interacting protein, 60kDa, isoform 3

Released:
DOI: 10.2210/pdb2ou2/pdb
PDB entry 2ou2 coloured by chain, front view.
PDB entry 2ou2 coloured by chain, side view.
PDB entry 2ou2 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Min J, Wu H, Dombrovski L, Loppnau P, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187828 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT5 Chain: A
Molecule details ›
Chain: A
Length: 280 amino acids
Theoretical weight: 32.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92993 (Residues: 227-506; Coverage: 55%)
Gene names: HTATIP, KAT5, TIP60
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand ACO 1 x ACO
1 bound ligand:
Ligand ZN 1 x ZN
1 modified residue:
Ligand ALY 1 x ALY

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I422
Unit cell:
a: 107.632Å b: 107.632Å c: 133.731Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.22 0.252
Expression system: Escherichia coli BL21(DE3)

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