› 2ova

X-ray diffraction
1.5Å resolution

X-ray structure of Human Complement Protein C8gamma Y83W Mutant

Released:
DOI: 10.2210/pdb2ova/pdb
PDB entry 2ova coloured by chain, front view.
PDB entry 2ova coloured by chain, side view.
PDB entry 2ova coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family.
Chiswell B, Lovelace LL, Brannen C, Ortlund EA, Lebioda L, Sodetz JM
Biochim Biophys Acta 1774 637-44 (2007)
PMID: 17452033

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139566 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement component C8 gamma chain Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 20.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07360 (Residues: 21-202; Coverage: 100%)
Gene name: C8G
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 42.256Å b: 58.938Å c: 71.996Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.219 0.225
Expression system: Escherichia coli

Quick links

Citations

2 review citations

The mystery behind membrane insertion: a review of the complement membrane attack complex.
Bayly-Jones et al. (2017)
1 more

1 mention without citation

PepPro: A Nonredundant Structure Data Set for Benchmarking Peptide-Protein Computational Docking.
Xu et al. (2020)