› 2ove

X-ray diffraction
2Å resolution

Crystal Structure of Recombinant Human Complement Protein C8gamma

Released:
DOI: 10.2210/pdb2ove/pdb
PDB entry 2ove coloured by chain, front view.
PDB entry 2ove coloured by chain, side view.
PDB entry 2ove coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family.
Chiswell B, Lovelace LL, Brannen C, Ortlund EA, Lebioda L, Sodetz JM
Biochim Biophys Acta 1774 637-44 (2007)
PMID: 17452033

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139566 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement component C8 gamma chain Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 20.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07360 (Residues: 21-202; Coverage: 100%)
Gene name: C8G
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P212121
Unit cell:
a: 42.227Å b: 59.775Å c: 71.901Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.226 0.26
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an "evolutionary bloom".
Charkoftaki et al. (2019)
5 other articles

2 mentions without citation

The mystery behind membrane insertion: a review of the complement membrane attack complex.
Bayly-Jones et al. (2017)
1 more