› 2ovh

X-ray diffraction
2Å resolution

Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor SMRT

Released:
DOI: 10.2210/pdb2ovh/pdb
PDB entry 2ovh coloured by chain, front view.
PDB entry 2ovh coloured by chain, side view.
PDB entry 2ovh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.
Madauss KP, Grygielko ET, Deng SJ, Sulpizio AC, Stanley TB, Wu C, Short SA, Thompson SK, Stewart EL, Laping NJ, Williams SP, Bray JD
Mol Endocrinol 21 1066-81 (2007)
PMID: 17356170

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-139038 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Progesterone receptor Chain: A
Molecule details ›
Chain: A
Length: 256 amino acids
Theoretical weight: 29.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06401 (Residues: 678-933; Coverage: 27%)
Gene names: NR3C3, PGR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
SMRT peptide Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 1.91 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand AS0 1 x AS0
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P3221
Unit cell:
a: 87.475Å b: 87.475Å c: 90.599Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.198 0.222
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

32 review citations

Endometriosis.
Bulun SE. (2009)
31 more

16 mentions without citation

Structural protein-ligand interaction fingerprints (SPLIF) for structure-based virtual screening: method and benchmark study.
Da et al. (2014)
15 more