› 2p0a

X-ray diffraction
1.9Å resolution

The crystal structure of human synapsin III (SYN3) in complex with AMPPNP

Released:
DOI: 10.2210/pdb2p0a/pdb
PDB entry 2p0a coloured by chain, front view.
PDB entry 2p0a coloured by chain, side view.
PDB entry 2p0a coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Turnbull AP, Phillips C, Pike ACW, Elkins JM, Gileadi C, Salah E, Niesen FH, Burgess N, Gileadi O, Gorrec F, Umeano C, von Delft F, Weigelt J, Edwards A, Arrowsmith CH, Sundstrom M, Doyle D, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127261 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synapsin-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 344 amino acids
Theoretical weight: 38.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14994 (Residues: 76-417; Coverage: 59%)
Gene name: SYN3
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand CL 2 x CL
Ligand SO4 6 x SO4
Ligand ANP 2 x ANP
Ligand EDO 8 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 130.796Å b: 73.186Å c: 78.398Å
α: 90° β: 100.74° γ: 90°
R-values:
R R work R free
0.183 0.181 0.218
Expression system: Escherichia coli

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