› 2p0r

X-ray diffraction
2.5Å resolution

Structure of Human Calpain 9 in complex with Leupeptin

Released:
DOI: 10.2210/pdb2p0r/pdb
PDB entry 2p0r coloured by chain, front view.
PDB entry 2p0r coloured by chain, side view.
PDB entry 2p0r coloured by chain, top view.
Source organisms:
Entry authors: Davis TL, Paramanathan R, Walker JR, Butler-Cole C, Finerty Jr PJ, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Dhe-Paganon S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127159 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calpain-9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 333 amino acids
Theoretical weight: 37.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14815 (Residues: 10-340; Coverage: 48%)
Gene names: CAPN9, NCL4
Sequence domains: Calpain family cysteine protease
Structure domains: Cysteine proteinases
leupeptin Chains: D, E
Molecule details ›
Chains: D, E
Length: 4 amino acids
Theoretical weight: 430 Da
Source organism: Streptomyces roseus
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CA 5 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P41212
Unit cell:
a: 97.165Å b: 97.165Å c: 173.378Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.21 0.269
Expression systems:
  • Escherichia coli
  • Not provided

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