› 2p0w

X-ray diffraction
1.9Å resolution

Human histone acetyltransferase 1 (HAT1)

Released:
DOI: 10.2210/pdb2p0w/pdb
PDB entry 2p0w coloured by chain, front view.
PDB entry 2p0w coloured by chain, side view.
PDB entry 2p0w coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wu H, Min J, Zeng H, Loppnau P, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127203 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone acetyltransferase type B catalytic subunit Chains: A, B
Molecule details ›
Chains: A, B
Length: 324 amino acids
Theoretical weight: 37.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14929 (Residues: 20-341; Coverage: 77%)
Gene names: HAT1, KAT1
Sequence domains:
Structure domains:
Histone peptide H4 Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 15 amino acids
Theoretical weight: 1.51 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments


Cofactor: Ligand ACO 2 x ACO
3 bound ligands:
Ligand ACT 1 x ACT
Ligand CL 1 x CL
Ligand ACM 4 x ACM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12B
Spacegroup: P21212
Unit cell:
a: 116.557Å b: 155.425Å c: 53.617Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.182 0.228
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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