› 2p28

X-ray diffraction
2.2Å resolution

Structure of the PHE2 and PHE3 fragments of the integrin beta2 subunit

Released:
DOI: 10.2210/pdb2p28/pdb
PDB entry 2p28 coloured by chain, front view.
PDB entry 2p28 coloured by chain, side view.
PDB entry 2p28 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins.
Shi M, Foo SY, Tan SM, Mitchell EP, Law SK, Lescar J
J Biol Chem 282 30198-206 (2007)
PMID: 17673459

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138493 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin beta-2 Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 11.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05107 (Residues: 23-122; Coverage: 13%)
Gene names: CD18, ITGB2, MFI7
Sequence domains: Integrin plexin domain
Structure domains:
Integrin beta-2 Chain: B
Molecule details ›
Chain: B
Length: 217 amino acids
Theoretical weight: 23.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05107 (Residues: 362-574; Coverage: 29%)
Gene names: CD18, ITGB2, MFI7
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P6522
Unit cell:
a: 52.26Å b: 52.26Å c: 423.924Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.263 0.261 0.308
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Integrin inside-out signaling and the immunological synapse.
Springer et al. (2012)
6 more

6 mentions without citation

Structural biology of complement receptors.
Santos-López et al. (2023)
5 more