› 2p31

X-ray diffraction
2Å resolution

Crystal structure of human glutathione peroxidase 7

Released:
DOI: 10.2210/pdb2p31/pdb
PDB entry 2p31 coloured by chain, front view.
PDB entry 2p31 coloured by chain, side view.
PDB entry 2p31 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kavanagh KL, Johansson C, Papagrigoriou E, Kochan G, Umeano C, Gileadi O, von Delft F, Weigelt J, Arrowsmith CH, Sundstrom M, Edwards A, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188755 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione peroxidase 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 181 amino acids
Theoretical weight: 20.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96SL4 (Residues: 20-177; Coverage: 94%)
Gene names: GPX6, GPX7, UNQ469/PRO828
Sequence domains: Glutathione peroxidase
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 32.046Å b: 56.224Å c: 94.593Å
α: 90° β: 91.27° γ: 90°
R-values:
R R work R free
0.166 0.163 0.215
Expression system: Escherichia coli BL21(DE3)

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