› 2p39

X-ray diffraction
1.5Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190457 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Fibroblast growth factor 23 N-terminal peptide Chain: A
Molecule details ›
Chain: A
Length: 155 amino acids
Theoretical weight: 17.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9GZV9 (Residues: 25-179; Coverage: 68%)
Gene names: FGF23, HYPF, UNQ3027/PRO9828
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

Carbohydrate polymer : NEW Components: GU4, YYJ
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 38.811Å b: 47.094Å c: 84.931Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.203 0.214
Expression system: Escherichia coli

Quick links

Citations

144 review citations

The FGF family: biology, pathophysiology and therapy.
Beenken et al. (2009)
143 more

17 mentions without citation

The structural biology of the FGF19 subfamily.
Beenken et al. (2012)
16 more