› 2p6v

X-ray diffraction
2Å resolution

Structure of TAFH domain of the human TAF4 subunit of TFIID

Released:
DOI: 10.2210/pdb2p6v/pdb
PDB entry 2p6v coloured by chain, front view.
PDB entry 2p6v coloured by chain, side view.
PDB entry 2p6v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conserved region I of human coactivator TAF4 binds to a short hydrophobic motif present in transcriptional regulators.
Wang X, Truckses DM, Takada S, Matsumura T, Tanese N, Jacobson RH
Proc Natl Acad Sci U S A 104 7839-44 (2007)
PMID: 17483474

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126223 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription initiation factor TFIID subunit 4 Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 12.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00268 (Residues: 575-688; Coverage: 11%)
Gene names: TAF2C, TAF2C1, TAF4, TAF4A, TAFII130, TAFII135
Sequence domains: NHR1 homology to TAF
Structure domains: TAFH/NHR1 domain

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
1 modified residue:
Ligand MLY 8 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P6322
Unit cell:
a: 74.852Å b: 74.852Å c: 131.785Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.214 0.248
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Structural basis of transcription initiation by RNA polymerase II.
Sainsbury et al. (2015)
7 more

8 mentions without citation

Macromolecular ab initio phasing enforcing secondary and tertiary structure.
Millán et al. (2015)
7 more