› 2pb7

X-ray diffraction
1.9Å resolution

Crystal Structure of the SRA domain of the human UHRF1 protein

Released:
DOI: 10.2210/pdb2pb7/pdb
PDB entry 2pb7 coloured by chain, front view.
PDB entry 2pb7 coloured by chain, side view.
PDB entry 2pb7 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Delagoutte B, Birck C, Samama JP

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188767 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase UHRF1 Chain: A
Molecule details ›
Chain: A
Length: 239 amino acids
Theoretical weight: 26.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96T88 (Residues: 408-643; Coverage: 30%)
Gene names: ICBP90, NP95, RNF106, UHRF1
Sequence domains: SAD/SRA domain
Structure domains: SRA-YDG

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P3221
Unit cell:
a: 53.929Å b: 53.929Å c: 161.995Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.205 0.227
Expression system: Escherichia coli BL21(DE3)

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