Function and Biology Details
Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
E3 ubiquitin-protein ligase RNF8 and peptide (preferred)
PDBe Complex ID:
PDB-CPX-131199 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
E3 ubiquitin-protein ligase RNF8
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 15.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: FHA domain
Structure domains: Tumour Suppressor Smad4
Length: 138 amino acids
Theoretical weight: 15.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
O76064 (Residues: 13-146; Coverage: 28%)
Sequence domains: FHA domain
Structure domains: Tumour Suppressor Smad4
