› 2pjl

X-ray diffraction
2.3Å resolution

Crystal Structure of Human Estrogen-Related Receptor alpha in Complex with a Synthetic Inverse Agonist reveals its Novel Molecular Mechanism

Released:
DOI: 10.2210/pdb2pjl/pdb
PDB entry 2pjl coloured by chain, front view.
PDB entry 2pjl coloured by chain, side view.
PDB entry 2pjl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism.
Kallen J, Lattmann R, Beerli R, Blechschmidt A, Blommers MJ, Geiser M, Ottl J, Schlaeppi JM, Strauss A, Fournier B
J Biol Chem 282 23231-9 (2007)
PMID: 17556356

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145853 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Steroid hormone receptor ERR1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 247 amino acids
Theoretical weight: 27.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11474 (Residues: 193-423; Coverage: 55%)
Gene names: ERR1, ESRL1, ESRRA, NR3B1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 047 2 x 047
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: R3
Unit cell:
a: 96.465Å b: 96.465Å c: 134.59Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.219 0.281
Expression system: Spodoptera frugiperda

Quick links

Citations

14 review citations

Pharmacological approaches to restore mitochondrial function.
Andreux et al. (2013)
13 more

8 mentions without citation

The Role of the Estrogen-Related Receptor Alpha (ERRa) in Hypoxia and Its Implications for Cancer Metabolism.
Chaltel-Lima et al. (2023)
7 more