› 2pkd

X-ray diffraction
2.04Å resolution

Crystal structure of CD84: Insite into SLAM family function

Released:
DOI: 10.2210/pdb2pkd/pdb
PDB entry 2pkd coloured by chain, front view.
PDB entry 2pkd coloured by chain, side view.
PDB entry 2pkd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of CD84 provides insight into SLAM family function.
Yan Q, Malashkevich VN, Fedorov A, Fedorov E, Cao E, Lary JW, Cole JL, Nathenson SG, Almo SC
Proc Natl Acad Sci U S A 104 10583-8 (2007)
PMID: 17563375

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193780 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SLAM family member 5 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 111 amino acids
Theoretical weight: 12.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UIB8 (Residues: 22-131; Coverage: 34%)
Gene names: CD84, SLAMF5
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9A, NSLS BEAMLINE X29A
Spacegroup: C2221
Unit cell:
a: 61.013Å b: 170.982Å c: 148.527Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.197 0.277
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

17 review citations

Follicular helper CD4 T cells (TFH).
Crotty S. (2011)
16 more

5 mentions without citation

Sequence, structure, function, immunity: structural genomics of costimulation.
Chattopadhyay et al. (2009)
4 more