› 2plz

X-ray diffraction
1.36Å resolution

Arg-modified human beta-defensin 1 (HBD1)

Released:
DOI: 10.2210/pdb2plz/pdb
PDB entry 2plz coloured by chain, front view.
PDB entry 2plz coloured by chain, side view.
PDB entry 2plz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.
Zou G, de Leeuw E, Li C, Pazgier M, Li C, Zeng P, Lu WY, Lubkowski J, Lu W
J Biol Chem 282 19653-65 (2007)
PMID: 17452329

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-defensin 1 Chain: A
Molecule details ›
Chain: A
Length: 36 amino acids
Theoretical weight: 4.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60022 (Residues: 33-68; Coverage: 77%)
Gene names: BD1, DEFB1, HBD1
Sequence domains: Beta defensin

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 20.366Å b: 27.408Å c: 55.079Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.108 0.105 0.158
Expression system: Escherichia coli

Quick links

Citations

11 review citations

α-Defensins in human innate immunity.
Lehrer et al. (2012)
10 more

2 mentions without citation

A polymorphic helix of a Salmonella needle protein relays signals defining distinct steps in type III secretion.
Guo et al. (2019)
1 more