› 2pn8

X-ray diffraction
1.8Å resolution

Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase)

Released:
DOI: 10.2210/pdb2pn8/pdb
PDB entry 2pn8 coloured by chain, front view.
PDB entry 2pn8 coloured by chain, side view.
PDB entry 2pn8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pilka ES, Kavanagh KL, Cooper C, von Delft F, Sundstrom M, Arrowsmith CA, Weigelt J, Edwards A, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171577 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-4 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 211 amino acids
Theoretical weight: 24.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13162 (Residues: 84-271; Coverage: 80%)
Gene name: PRDX4
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 96.188Å b: 138.776Å c: 108.989Å
α: 90° β: 104.52° γ: 90°
R-values:
R R work R free
0.153 0.151 0.185
Expression system: Escherichia coli

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