2pno

X-ray diffraction
3.3Å resolution

Crystal structure of human leukotriene C4 synthase

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo trimer (preferred)
PDBe Complex ID:
PDB-CPX-172606 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukotriene C4 synthase Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 156 amino acids
Theoretical weight: 17.41 KDa
Source organism: Homo sapiens
Expression system: Schizosaccharomyces pombe
UniProt:
  • Canonical: Q16873 (Residues: 1-150; Coverage: 100%)
Gene name: LTC4S
Sequence domains: MAPEG family
Structure domains: Membrane associated eicosanoid/glutathione metabolism-like domain

Ligands and Environments


Cofactor: Ligand GSH 12 x GSH
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44B2
Spacegroup: C2221
Unit cell:
a: 117.5Å b: 293.9Å c: 206.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.221 0.255
Expression system: Schizosaccharomyces pombe