› 2pom

X-ray diffraction
2.27Å resolution

TAB1 with manganese ion

Released:
DOI: 10.2210/pdb2pom/pdb
PDB entry 2pom coloured by chain, front view.
PDB entry 2pom coloured by chain, side view.
PDB entry 2pom coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization.
Lu M, Lin SC, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H
Mol Cell 26 689-702 (2007)
PMID: 17560374

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172388 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 372 amino acids
Theoretical weight: 40.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q15750 (Residues: 1-370; Coverage: 73%)
Gene names: MAP3K7IP1, TAB1
Sequence domains: Protein phosphatase 2C
Structure domains: PPM-type phosphatase domain

Ligands and Environments

1 bound ligand:
Ligand MN 1 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P321
Unit cell:
a: 141.618Å b: 141.618Å c: 66.153Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.211 0.211 0.233
Expression system: Escherichia coli K-12

Quick links

Citations

60 review citations

NF-κB, the first quarter-century: remarkable progress and outstanding questions.
Hayden et al. (2012)
59 more

5 mentions without citation

Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15).
Ivanov et al. (2015)
4 more