› 2pv0

X-ray diffraction
3.3Å resolution

DNA methyltransferase 3 like protein (DNMT3L)

Released:
DOI: 10.2210/pdb2pv0/pdb
PDB entry 2pv0 coloured by chain, front view.
PDB entry 2pv0 coloured by chain, side view.
PDB entry 2pv0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.
Ooi SK, Qiu C, Bernstein E, Li K, Jia D, Yang Z, Erdjument-Bromage H, Tempst P, Lin SP, Allis CD, Cheng X, Bestor TH
Nature 448 714-7 (2007)
PMID: 17687327

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193821 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA (cytosine-5)-methyltransferase 3-like Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 386 amino acids
Theoretical weight: 43.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9UJW3 (Residues: 1-386; Coverage: 100%)
Gene name: DNMT3L
Sequence domains:
Structure domains: Vaccinia Virus protein VP39

Ligands and Environments

1 bound ligand:
Ligand ZN 9 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID, null
Spacegroup: P6122
Unit cell:
a: 267.2Å b: 267.2Å c: 149.5Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.248 0.248 0.272
Expression system: Escherichia coli BL21

Quick links

Citations

370 review citations

Functions of DNA methylation: islands, start sites, gene bodies and beyond.
Jones PA. (2012)
369 more

5 mentions without citation

Mammalian DNA methyltransferases: a structural perspective.
Cheng et al. (2008)
4 more