› 2q0n

X-ray diffraction
1.75Å resolution

Structure of human p21 activating kinase 4 (PAK4) in complex with a consensus peptide

Released:
DOI: 10.2210/pdb2q0n/pdb
PDB entry 2q0n coloured by chain, front view.
PDB entry 2q0n coloured by chain, side view.
PDB entry 2q0n coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Eswaran J, Turnbull A, Papagrigoriou E, Pike AW, von Delft F, Sundstrom M, Edwards A, Arrowsmith CH, Weigelt J, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132124 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein kinase PAK 4 Chain: A
Molecule details ›
Chain: A
Length: 301 amino acids
Theoretical weight: 34.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O96013 (Residues: 291-591; Coverage: 51%)
Gene names: KIAA1142, PAK4
Sequence domains: Protein kinase domain
Structure domains:
Synthetic peptide Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.56 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand EDO 8 x EDO
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P43212
Unit cell:
a: 145.678Å b: 145.678Å c: 39.577Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.182 0.228
Expression systems:
  • Escherichia coli
  • Not provided

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