› 2q3g

X-ray diffraction
1.11Å resolution

Structure of the PDZ domain of human PDLIM7 bound to a C-terminal extension from human beta-tropomyosin

Released:
DOI: 10.2210/pdb2q3g/pdb
PDB entry 2q3g coloured by chain, front view.
PDB entry 2q3g coloured by chain, side view.
PDB entry 2q3g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms.
Elkins JM, Gileadi C, Shrestha L, Phillips C, Wang J, Muniz JR, Doyle DA
Protein Sci 19 731-41 (2010)
PMID: 20120020

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192526 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PDZ and LIM domain protein 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 89 amino acids
Theoretical weight: 9.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NR12 (Residues: 1-84; Coverage: 18%)
Gene names: ENIGMA, PDLIM7
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

2 bound ligands:
Ligand EDO 3 x EDO
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 46.052Å b: 55.404Å c: 57.316Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.133 0.131 0.157
Expression system: Escherichia coli

Quick links

Citations

4 review citations

PDZ Domains as Drug Targets.
Christensen et al. (2019)
3 more

4 mentions without citation

Specificity in PDZ-peptide interaction networks: Computational analysis and review.
Amacher et al. (2020)
3 more