Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147174 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (7 distinct):
Leukemia inhibitory factor receptor
Molecule details ›
Chains: A, C
Length: 488 amino acids
Theoretical weight: 55.02 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
Sequence domains:
Length: 488 amino acids
Theoretical weight: 55.02 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
- Canonical:
P42703 (Residues: 50-529; Coverage: 46%)
Sequence domains:
- Leukemia inhibitory factor receptor N-terminal domain
- Leukemia inhibitory factor receptor D2 domain
- Leukemia inhibitory factor receptor, Ig-like domain
- Fibronectin type III domain
Leukemia inhibitory factor
Molecule details ›
Chains: B, D
Length: 180 amino acids
Theoretical weight: 19.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: LIF / OSM family
Structure domains: Growth Hormone; Chain: A;
Length: 180 amino acids
Theoretical weight: 19.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P15018 (Residues: 23-202; Coverage: 100%)
Sequence domains: LIF / OSM family
Structure domains: Growth Hormone; Chain: A;
Ligands and Environments
1 bound ligand:
No modified residues
Experiments and Validation Details
X-ray source:
APS BEAMLINE 22-ID
Spacegroup:
C2221
Expression systems:
- Cricetulus griseus
- Escherichia coli
