2q9i

X-ray diffraction
2.8Å resolution

Crystal Structure of D-Dimer from Human Fibrin Complexed with Met-His-Arg-Pro-Tyr-amide.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-136012 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (6 distinct):
Fibrinogen alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 87 amino acids
Theoretical weight: 10.24 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02671 (Residues: 130-216; Coverage: 10%)
Gene name: FGA
Sequence domains: Fibrinogen alpha/beta chain family
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Fibrinogen beta chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 328 amino acids
Theoretical weight: 37.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02675 (Residues: 164-491; Coverage: 71%)
Gene name: FGB
Sequence domains:
Structure domains:
Fibrinogen gamma chain Chains: C, F
Molecule details ›
Chains: C, F
Length: 324 amino acids
Theoretical weight: 36.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02679 (Residues: 114-433; Coverage: 75%)
Gene names: FGG, PRO2061
Sequence domains:
Structure domains:
Fibrin B Knob (GHRPam) Chains: S, T
Molecule details ›
Chains: S, T
Length: 4 amino acids
Theoretical weight: 468 Da
Fibrin B Knob (MHRPYam) Chains: M, N
Molecule details ›
Chains: M, N
Length: 5 amino acids
Theoretical weight: 705 Da

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 54.38Å b: 147.23Å c: 231.48Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.276