› 2qbp

X-ray diffraction
2.5Å resolution

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148259 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 1 Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18031 (Residues: 1-299; Coverage: 69%)
Gene names: PTP1B, PTPN1
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand 527 1 x 527
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P3121
Unit cell:
a: 88.456Å b: 88.456Å c: 104.29Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.209 0.245
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.
Kappe et al. (2009)
9 more

12 mentions without citation

Methyl effects on protein-ligand binding.
Leung et al. (2012)
11 more