› 2qep

X-ray diffraction
2.5Å resolution

Crystal structure of the D1 domain of PTPRN2 (IA2beta)

Released:
DOI: 10.2210/pdb2qep/pdb
PDB entry 2qep coloured by chain, front view.
PDB entry 2qep coloured by chain, side view.
PDB entry 2qep coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell 136 352-63 (2009)
PMID: 19167335

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187816 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
IA-2beta60 Chains: A, B
Molecule details ›
Chains: A, B
Length: 304 amino acids
Theoretical weight: 34.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92932 (Residues: 715-1010; Coverage: 30%)
Gene names: KIAA0387, PTPRN2
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21212
Unit cell:
a: 131.541Å b: 136.555Å c: 35.752Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.236 0.286
Expression system: Escherichia coli

Quick links

Citations

59 review citations

Inside the human cancer tyrosine phosphatome.
Julien et al. (2011)
58 more

1 mention without citation

The core cysteines, (C909) of islet antigen-2 and (C945) of islet antigen-2β, are crucial to autoantibody binding in type 1 diabetes.
Elvers et al. (2013)