› 2qhm

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127093 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase Chk1 Chain: A
Molecule details ›
Chain: A
Length: 323 amino acids
Theoretical weight: 36.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14757 (Residues: 1-307; Coverage: 65%)
Gene names: CHEK1, CHK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 7CS 1 x 7CS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 45.15Å b: 66.07Å c: 58.21Å
α: 90° β: 94.36° γ: 90°
R-values:
R R work R free
0.195 0.192 0.237
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Recent Advances in One-Pot Modular Synthesis of 2-Quinolones.
Hong et al. (2020)
12 other articles

4 mentions without citation

The azaindole framework in the design of kinase inhibitors.
Mérour et al. (2014)
3 more