› 2qk0

X-ray diffraction
2Å resolution

Structural Basis of Microtubule Plus End Tracking by XMAP215, CLIP-170 and EB1

Released:
DOI: 10.2210/pdb2qk0/pdb
PDB entry 2qk0 coloured by chain, front view.
PDB entry 2qk0 coloured by chain, side view.
PDB entry 2qk0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1.
Slep KC, Vale RD
Mol Cell 27 976-91 (2007)
PMID: 17889670

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151773 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CAP-Gly domain-containing linker protein 1 Chain: A
Molecule details ›
Chain: A
Length: 74 amino acids
Theoretical weight: 8.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30622 (Residues: 57-128; Coverage: 5%)
Gene names: CLIP1, CYLN1, RSN
Sequence domains: CAP-Gly domain
Structure domains: CAP Gly-rich-like domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 1 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P212121
Unit cell:
a: 27.242Å b: 42.533Å c: 51.806Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.173 0.233
Expression system: Escherichia coli

Quick links

Citations

35 review citations

Tracking the ends: a dynamic protein network controls the fate of microtubule tips.
Akhmanova et al. (2008)
34 more

1 mention without citation

Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1.
Slep et al. (2007)