Function and Biology Details
Reactions catalysed:
10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Phosphoribosylglycinamide synthetase, C-domain
- Phosphoribosylglycinamide synthetase
- Phosphoribosylglycinamide synthetase, C-domain superfamily
- Rudiment single hybrid motif
- Phosphoribosylglycinamide synthetase, conserved site
- ATP-grasp fold, subdomain 1
- ATP-grasp fold
- Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
2 more domains
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149522 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trifunctional purine biosynthetic protein adenosine-3
Molecule details ›
Chains: A, B
Length: 452 amino acids
Theoretical weight: 48.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 452 amino acids
Theoretical weight: 48.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P22102 (Residues: 1-430; Coverage: 43%)
Sequence domains:
- Phosphoribosylglycinamide synthetase, N domain
- Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
- Phosphoribosylglycinamide synthetase, C domain
