› 2ql1

X-ray diffraction
2.53Å resolution

Structural Characterization of a Mutated, ADCC-Enhanced Human Fc Fragment

Released:
DOI: 10.2210/pdb2ql1/pdb
PDB entry 2ql1 coloured by chain, front view.
PDB entry 2ql1 coloured by chain, side view.
PDB entry 2ql1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterization of a mutated, ADCC-enhanced human Fc fragment.
Oganesyan V, Damschroder MM, Leach W, Wu H, Dall'Acqua WF
Mol Immunol 45 1872-82 (2008)
PMID: 18078997

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Immunoglobulin heavy constant gamma 1 Chain: A
Molecule details ›
Chain: A
Length: 225 amino acids
Theoretical weight: 25.45 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01857 (Residues: 106-328; Coverage: 56%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, FUC
Carbohydrate polymer
1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: C2221
Unit cell:
a: 49.869Å b: 147.492Å c: 74.315Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.232 0.293
Expression system: Not provided

Quick links

Citations

15 review citations

IgG Fc engineering to modulate antibody effector functions.
Wang et al. (2018)
14 more

6 mentions without citation

Function and 3D structure of the N-glycans on glycoproteins.
Nagae et al. (2012)
5 more