2qnv

X-ray diffraction
2.8Å resolution

Crystal Structure of the Pregnane X Receptor bound to Colupulone

Released:
Source organism: Homo sapiens
Entry authors: Teotico DG, Bischof J, Redinbo MR

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-130972 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 1 group I member 2 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 36.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75469 (Residues: 130-434; Coverage: 70%)
Gene names: NR1I2, PXR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 90.865Å b: 90.865Å c: 85.41Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.242 0.284
Expression system: Escherichia coli BL21(DE3)