› 2qqi

X-ray diffraction
1.8Å resolution

Crystal Structure of the b1b2 Domains from Human Neuropilin-1

Released:
DOI: 10.2210/pdb2qqi/pdb
PDB entry 2qqi coloured by chain, front view.
PDB entry 2qqi coloured by chain, side view.
PDB entry 2qqi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.
Appleton BA, Wu P, Maloney J, Yin J, Liang WC, Stawicki S, Mortara K, Bowman KK, Elliott JM, Desmarais W, Bazan JF, Bagri A, Tessier-Lavigne M, Koch AW, Wu Y, Watts RJ, Wiesmann C
EMBO J 26 4902-12 (2007)
PMID: 17989695

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127136 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuropilin-1 Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 36.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14786 (Residues: 273-586; Coverage: 35%)
Gene names: NRP, NRP1, VEGF165R
Sequence domains: F5/8 type C domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P212121
Unit cell:
a: 65.92Å b: 66.979Å c: 74.679Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.159 0.201
Expression system: Escherichia coli

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Citations

55 review citations

Role and therapeutic potential of VEGF in the nervous system.
Ruiz de Almodovar et al. (2009)
54 more

16 mentions without citation

Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.
Appleton et al. (2007)
15 more