› 2r2o

X-ray diffraction
2Å resolution

Crystal structure of the effector domain of human Plexin B1

Released:
DOI: 10.2210/pdb2r2o/pdb
PDB entry 2r2o coloured by chain, front view.
PDB entry 2r2o coloured by chain, side view.
PDB entry 2r2o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain.
Tong Y, Chugha P, Hota PK, Alviani RS, Li M, Tempel W, Shen L, Park HW, Buck M
J Biol Chem 282 37215-24 (2007)
PMID: 17916560

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plexin-B1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 138 amino acids
Theoretical weight: 15.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43157 (Residues: 1743-1862; Coverage: 6%)
Gene names: KIAA0407, PLXN5, PLXNB1, SEP
Sequence domains: Plexin cytoplasmic RhoGTPase-binding domain
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

1 bound ligand:
Ligand UNX 12 x UNX
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B, APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 50.979Å b: 56.571Å c: 99.366Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.269
Expression system: Escherichia coli

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Citations

20 review citations

The semaphorins: versatile regulators of tumour progression and tumour angiogenesis.
Neufeld et al. (2008)
19 more

8 mentions without citation

Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain.
Tong et al. (2007)
7 more